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In a recent study, the safety and efficacy of venlafaxine (75 mg) was evaluated in 41 patients with painful DPN, in whom gabapentin was failing (265). Patients received venlafaxine daily for 4 weeks in the absence of adequate response to usual doses of gabapentin (300-900 mg/day). A total of 81.7% of patients were responders, and the clinical response to gabapentin was well maintained after treatment with venlafaxine. From pretreatment to week 4, the mean (SEM) score of NPSI-2 items decreased significantly (P 827ec27edc