CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
The human body can synthesize significant amounts of dimethylglycine by metabolizing choline or losing one trimethylglycine methyl group through the homocysteine pathway. However, DMG is broken down so quickly and used in so many different pathways that its levels are spread thin and never get a chance to build up. As such, the most effective way of increasing quantities of dimethylglycine in the human body is through supplementation.
Results showed consistent data points to the possibility of DMG deficiency playing a causal role in insulin resistance development. This study sparks the need for further studies to examine the inhibition of DMG-dehydrogenase (possible protective effects of DMG on glucose metabolism DMGDH-catalyzed reaction) and points to possibilities that DMG supplementation may be useful to maintain a normal insulin response.*
GLUCONIC® DMG is a dietary supplement to support the immune system, circulatory, cardiovascular, neurological functions, muscle recovery, and endurance.* Gluconic® DMG is an adaptogen that can be used to maintain good health and benefit performance and productivity.* As a metabolic enhancer, DMG supports the body in times of stress, throughout the aging process, and during immune system challenges.* Learn More
This is a dietary supplement to support the immune system, circulatory, cardiovascular and neurological functions, as well as muscle recovery and endurance.* DMG supports lactic acid metabolism during workouts, thereby supporting recovery and endurance.* Learn More
A dietary supplement to support heart health and energy function.* Ingredients include 300 mg of DMG, 300 mg of COQ10, and 5 IU of Vitamin E. Other ingredients include: mannitol powder, xylitol, stearic acid, silicon dioxide, vegetable stearate, and citric acid. Learn More
A dietary supplement to support brain and neurological functions.* This formula was designed for individuals who have difficulty with memory or recall, thought focus, and following information or conversations.* Learn More
A dietary supplement to support proper joint and connective tissue functions.* The effectiveness of Perna® Plus is due to the unique biological activity of the many identified nutrients in the Perna mussel combined with Glucosamine, Methylsulfonylmethane (MSM), Dimethylglycine (DMG), and Manganese. Learn More
DMG or dimethylglycine is a derivitive of the simplest amino acid, glycine. It is an adaptogen, a metabolic enhancer, and methyl donor. It is a natural substance found in low levels in the body and in certain foods like meat (liver), beans, seeds, and grains. Humans and animals produce DMG in small amounts, and it affects nearly every metabolic pathway within the cell. Initially used as a performance enhancer for Russian athletes and cosmonauts, this dietary supplement helps to support immune system, circulatory, cardiovascular and neurological functions, muscle recovery and endurance, and so much more. DMG is an intricate part of human metabolism and has been used in the health field as a nutritional supplement for over 25 years.
EnerDMG is s dietary supplement to support immune system, circulatory, cardiovascular and neurological functions, muscle recovery and endurance. It is an adaptogen that can be used to maintain good health and benefit performance and productivity. As a metabolic enhancer, DMG supports the body in times of stress, throughout the aging process, and during immune system challenges.
Dimethylglycine (DMG) is a supplement that is often used as a performance enhancer in racing animals such as dogs and horses for its alleged ability to reduce lactic acid buildup and therefore its ability to reduce muscle fatigue. It is a derivative of the amino acid glycine and is a natural product of choline metabolism in the body. Other reported uses/benefits have been for autism, seizures, lupus, melanoma, diabetes, chronic fatigue syndrome, and improved immune and cardiovascular function in humans, although many of these uses have not been strongly corroborated by robust scientific studies.
There are differences in how countries regulate supplements. In the United States, these substances are not as vigorously regulated by the FDA as other medications, which means they can be sold without the manufacturer proving their effectiveness, safety, and without a guarantee of consistent or accurately reported ingredients. In Canada, products that have been evaluated for quality, safety, and effectiveness by Health Canada and authorized for sale will have a license number on the label.
Vitamins, herbal therapies, and supplements have the potential to interact with each other, as well as with prescription and over the counter medications. It is important to tell your veterinarian about any medications (including all vitamins, supplements, or herbal therapies) that your pet is taking.
Data in humans are also quite limited. A few studies suggest DMG may help enhance both humoral and cell-mediated immune responses (2). However, DMG had no effect on oxygen consumption in children with SLSJ-COX deficiency (7), and its use to treat seizures or autism stays controversial as limited clinical trials have yielded mixed results (1) (8). In addition, a systematic review of supplements found no effects with DMG for autism symptoms (11).
Enhanced physical performance in animals with DMG supplementation may occur via improved oxygen utilization and reduced lactic acid formation. In humans, it is thought to enhance humoral and cell-mediated immune responses (2). No mechanisms have been uncovered to elucidate claims of DMG for autism, ADHD, epilepsy, chronic fatigue syndrome, or athletic performance enhancement. A recent metabolic analysis of healthy subjects correlated high plasma cholesterol levels with low levels for some metabolites related to mitochondrial metabolism including dimethylglycine (9).
DMG has been suggested as a beneficial supplement and has been used to combat fatigue, improve metabolism, and strengthen the immune system [1, 2]. On the back of these, some nutritional companies have included DMG in their products and made claims that it has beneficial effects on endurance performance by combating fatigue and enhancing metabolism.
However, there is at present, little evidence to back up these claims. Most research appears to point to there being little or no benefit to DMG supplementation . For example, tested with college athletes, DMG increased maximum oxygen absorption. Athletes taking DMG had a 23.6% increase over placebo control in the length of exercise time before exhaustion . The results of these studies could not be verified in adults and children [8, 9].
Research studies concerning DMG and MS are not available. A recently published review about other dietary interventions in MS shows inefficient evidence of whether supplementation with antioxidants, omega-3, omega-6, or vitamin D has any impact on MS-related outcomes .
DMG is an adaptogen that can be used to maintain good health and benefit performance and productivity.* As a metabolic enhancer, DMG supports the body in times of stress, throughout the aging process, and during immune system challenges. DMG is an intricate part of human metabolism and has been used in the health field as a nutritional supplement for over 25 years.
Research and clinical experience has shown that DMG supplementation supports:~Physical and mental performance.~Oxygen utilization, Asthma, and COPD~Strengthening of both arms of the immune system, including antibody, lymphocyte and cytokine production.~Detoxification, especially in the liver.~Circulation and vascular health.~Glucose and fat metabolism.~Blood pressure, cholesterol, triglycerides, and homocysteine levels within normal ranges.~Physical and mental energy levels by reducing lactic acid build-up during periods of stress.~Mental alertness and brain function.~Overall body health by acting as an indirect methyl donor and providing useful building units for the biosynthesis of vitamins, hormones, neurotransmitters, antibodies, and nucleic acids.
The effect of dietary supplementation with N,N-dimethylglycine sodium salt (Na-DMG) was evaluated in a feeding trial with 1500 1-day-old broiler chicks (Cobb 500). DMG was supplemented at 0, 0.1, 0.2, 0.5 or 1 g Na-DMG/kg feed to a ration with either animal fat (chicken fat) or vegetal fat (soy oil) as main fat source. In the vegetal fat diets, production value was significantly linearly improved by supplementation with DMG up to 11%. Irrespective of dietary fat source, abdominal fat percentage was significantly linearly reduced up to 24% and meat yield tended to increase linearly with DMG level up to 4%. In the vegetal fat groups, DMG significantly lowered abdominal fat pad by up to 38% and tended to increase meat yield up to 6% at the highest dose. Fasted non-esterified fatty acid level significantly decreased with increasing DMG level up to 36% and thiobarbituric acid reactive species (TBARS) decreased with a statistical trend up to 46% at the highest dose. In vegetal fat diets, addition of DMG resulted in significant lower TBARS level by 56% at the highest dose. Finally, a significant quadratic effect on ascites heart index was present in the vegetal fat diets, with a minimal value at 0.5 g Na-DMG/kg. In conclusion, dietary supplementation with DMG may improve technical and slaughter performance, and may reduce oxidative stress and pulmonary hypertension, but the degree of effects is modulated by fatty acid profile of the diet. Herewith, effects are more pronounced in a diet rich in polyunsaturated fatty acids compared with a diet rich in saturated and monounsaturated fatty acids. 2b1af7f3a8